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Thirst and excessive urination, nausea and diarrhea and tremor are rather common side effects that are typically no more than annoying even though they are rather prevalent. This paper summarizes the knowledge base on side effects and toxicity and suggests optimal management of these problems. Additionally, side effect concerns assuredly play some role in lithium nonadherence. Although this observation is multifactorial, one obvious potential contributor is the side effect and toxicity burden associated with lithium. Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently.
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